心筋代謝
研究の紹介-ラットの摘出心臓標本
研究メンバー
小口健史
中楯陽介
川上亜希子
松岡徹
大宮啓輔
実験モデルの特長
- 血液を含まない晶質液で心臓のみを灌流する。
- 神経系、血管系、他臓器の影響を排除できる。
- 左心室機能、冠循環、心筋代謝について研究できる。
- 心筋のカルシウム動態、スーパーオキサイド発生量、サイトカイン産生量などが測定可能
蛍光色素負荷型摘出心臓モデル
実験装置
最近の研究内容
Acute Hyperglycemia Diminishes Cardioprotective Effects of High Dose Insulin in the Ischemic Rat Heart. American Society of Anesthesiologists Annual Meeting 2014
Ulinastatin, A Protease Inhibitor, Attenuates Protamine-Induced Cardiotoxicity in Rats by Inhibiting Tumor Necrosis Factor Alpha. American Society of Anesthesiologists Annual Meeting 2011
Ulinastatin Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart
American Society of Anesthesiologists Annual Meeting 2010: A699
TNF-alpha-Induced Cardiotoxicity Is Prevented by Ulinastatin in Isolated Rat Hearts
American Society of Anesthesiologists Annual Meeting 2009: A1305
Distribution of nitric oxide synthase isoforms in a porcine endotoxin shock model.
Shock 29: 6; 692-702, 2008.
A Novel Sedative Agent, Jm-1232(-), Reduces Dysrhythmias during Reperfusion in Ischemic Rat Hearts. American Society of Anesthesiologists Annual Meeting 2008: A307
Protamine-Induced Cardiotoxicity Is Prevented by Ulinastatin in Isolated Rat Hearts
Hearts. American Society of Anesthesiologists Annual Meeting 2007: A1330
Glyburide Prevents Isoflurane’s Reducing Effects on Hydroxyl Radical Formation in the Postischemic Reperfused Rat Heart. Experimental & Clinical Cardiology, 7(1):25-29, 2002
研究の紹介「ラットの摘出心臓標本」
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